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Increased d-lactic acid intestinal bacteria in patients with CFS
Saturday 8 August 2009
Increased d-lactic acid intestinal bacteria in patients with chronic fatigue syndrome - Source: In Vivo, Jul-Aug, 2009
by John R Sheedy, Kenny L De Meirleir, et al.
July 2, 2009
Patients with chronic fatigue syndrome (CFS) are affected by symptoms of cognitive dysfunction and neurological impairment, the cause of which has yet to be elucidated.
However, these symptoms are strikingly similar to those of patients presented with D-lactic acidosis.
A significant increase of Gram positive facultative anaerobic faecal microorganisms in 108 CFS patients as compared to 177 control subjects (p<0.01) is presented in this report.
The viable count of D-lactic acid producing Enterococcus and Streptococcus spp. in the faecal samples from the CFS group (3.5×107 cfu/L and 9.8×107 cfu/L respectively) were significantly higher than those for the control group (5.0×106 cfu/L and 8.9×104 cfu/L respectively).
Analysis of exometabolic profiles of Enterococcus faecalis and Streptococcus sanguinis, representatives of Enterococcus and Streptococcus spp. respectively, by NMR and HPLC showed that these organisms produced significantly more lactic acid (p<0.01) from 13C-labeled glucose, than the Gram negative Escherichia coli.
Further, both E. faecalis and S. sanguinis secrete more D-lactic acid than E. coli.
This study suggests a probable link between intestinal colonization of Gram positive facultative anaerobic D-lactic acid bacteria and symptom expressions in a subgroup of patients with CFS.
Given the fact that this might explain not only neurocognitive dysfunction in CFS patients but also mitochondrial dysfunction, these findings may have important clinical implications.
Source: In Vivo, Jul-Aug, 2009;23(4):621-8. PMID: 19567398 Sheedy JR, Wettenhall RE, Scanlon D, Gooley PR, Lewis DP, McGregor N, Stapleton DI, Butt HL, De Meirleir KL. Vrije Universiteit Brussel, Brussels, Belgium. [E-mail: Kenny.De.Meirleir@vub.ac.be]
The article originally appeared here.
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