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New XMRV results published in Retrovirology

Friday 19 February 2010

RetrovirologyNew research into XMRV published in Retrovirology has reinforced the UK results that showed a lack of XMRV in CFS patients:

Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome

Harriet C T Groom, Virginie C Boucherit, Kerry Makinson, Edward Randal, Sarah Baptista, Suzanne Hagan, John W Gow, Frank M Mattes, Judith Breuer, Jonathan R Kerr, Jonathan P Stoye and Kate N Bishop

Retrovirology 2010, 7:10doi:10.1186/1742-4690-7-10

Published: 15 February 2010

Abstract (provisional)

Background

Detection of a retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), has recently been reported in 67% of patients with chronic fatigue syndrome. We have studied a total of 170 samples from chronic fatigue syndrome patients from two UK cohorts and 395 controls for evidence of XMRV infection by looking either for the presence of viral nucleic acids using quantitative PCR (limit of detection <16 viral copies) or for the presence of serological responses using a virus neutralisation assay.

Results

We have not identified XMRV DNA in any samples by PCR (0/299). Some serum samples showed XMRV neutralising activity (26/565) but only one of these positive sera came from a CFS patient. Most of the positive sera were also able to neutralise MLV particles pseudotyped with envelope proteins from other viruses, including vesicular stomatitis virus, indicating significant cross-reactivity in serological responses. Four positive samples were specific for XMRV.

Conclusions

No association between XMRV infection and CFS was observed in the samples tested, either by PCR or serological methodologies. The non-specific neutralisation observed in multiple serum samples suggests that it is unlikely that these responses were elicited by XMRV and highlights the danger of over-estimating XMRV frequency based on serological assays. In spite of this, we believe that the detection of neutralising activity that did not inhibit VSV-G pseudotyped MLV in at least four human serum samples indicates that XMRV infection may occur in the general population, although with currently uncertain outcomes.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

The above abstract originally appeared here.

Reports of (and responses to) the research results have been numerous:

19/02/10

HealthDay
Chronic Fatigue Syndrome-Virus Link Questioned
(US)

19/02/10

Bringing the Heat: An ME/CFS Blog
A Guide to XMRV Research: the WPI Answers Back
(US)

18/02/10

The ME Association
Whittemore Peterson Institute respond to second UK study into XMRV and ME/CFS
(UK)

17/02/10

The ME Association
New Challenge to Chronic Fatigue 'Virus' - ScienceNOW magazine
(UK)

17/02/10

The ME Association
CFIDS Association of America comment on second UK study into XMRV and ME/CFS
(UK)

17/02/10

CFIDS Association of America
Still In Search of a Proper and Robust Replication Study
(US)

17/02/10

The ME Association
XMRV and ME/CFS - summary and MEA position statement on second UK study published in Retrovirology
(UK)

16/02/10

Phoenix Rising
The XMRV Buzz! - the Chronic Fatigue Syndrome / XMRV News Page
(US)

16/02/10

ScienceNOW
New Challenge to Chronic Fatigue 'Virus'
(US)

15/02/10

ProHealth
Absence of xenotropic murine leukemia virus-related virus in UK patients with chronic fatigue syndrome – Source: Retrovirology, Feb 15, 2010
(US)

15/02/10

Virology Blog
XMRV not found in 170 additional UK chronic fatigue syndrome patients
(US)

 


 

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