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XMRV: third study fails to find virus

Monday 1 March 2010

BMJEurekaAlert! reports:

New study casts doubt over ME virus link

Research: Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort

A new study published on today casts doubt on recent claims that a human retrovirus known as XMRV is linked to chronic fatigue syndrome or ME (myalgic encephalitis).

This is the third study to refute the original US study reporting the link.

Chronic fatigue syndrome is a debilitating condition that affects millions of people worldwide with disabling physical and mental fatigue that does not improve with rest. Its causes remain unclear, but many people say their illness started after a viral infection.

A recent study from the United States detected XMRV in two thirds of patients with chronic fatigue syndrome, but could not conclusively prove a direct (causal) link between the virus and the disease.

In January 2010, another research team found no evidence of XMRV in 186 patients with chronic fatigue syndrome in the United Kingdom. A third study, published earlier this month, also failed to identify XMRV in 170 patients.

So a team from the Netherlands, led by Professors Frank van Kuppeveld and Jos van der Meer, investigated whether this link could be confirmed in an independent European group of patients with chronic fatigue syndrome.

They examined the DNA from XMRV in the blood cells of 32 Dutch patients with chronic fatigue syndrome and 43 healthy controls, matched by age, sex and geographical area. Two highly sensitive tests were performed on two different target genes.

They found no evidence of XMRV in any of the patients or the controls, adding to the negative evidence in the two previous studies.

"Although our patient group was relatively small and we cannot formally rule out a role of XMRV, our data cast doubt on the claim that this virus is associated with chronic fatigue syndrome in the majority of patients," say the authors.

One reason why these results contradict the original findings may be that the US study involved patients from a specific outbreak of chronic fatigue syndrome in the mid-80s that has already been linked to several viruses, explain the authors. It is possible that XMRV is implicated in this outbreak, but does not play a substantial role in most cases of chronic fatigue syndrome elsewhere, they conclude.

To reconcile these different findings, other US laboratories are currently investigating XMRV and chronic fatigue syndrome, and the results are eagerly awaited, say researchers from Imperial College London and King's College London in an accompanying editorial.

"If the link fails to hold up, it will be another bitter disappointment to affected patients. Nonetheless, the current debate will still bring critical attention to the causes of chronic fatigue syndrome, and XMRV may turn out to be important in the pathogenesis of other diseases," they conclude.

The above article originally appeared here.

The full abstract at BMJ can be found here.

News and editorials about the third XMRV study is growing:


Phoenix Rising
The XMRV Files - The Mystery Continues (March, 2010) by Cort Johnson

02/03/10 Fibromyalgia & Chronic Fatigue
XMRV & Chronic Fatigue Syndrome: Negative Study #3, But So What?


Prostate virus does not cause chronic fatigue


MedPage Today
XMRV Not Linked to Chronic Fatigue Syndrome


Los Angeles Times
Third study finds no link between mouse virus and chronic fatigue syndrome


The ME Association
XMRV and ME/CFS – Third negative study reported in the British Medical Journal

26/02/10 (Financial Times)
Study hits hopes for ME cure
(second item on page, after "Breakthrough on converting biofuel") (US)


TopNews United States
Study Triggers Doubts on Virus-chronic Fatigue Syndrome


New study finds virus not linked to Chronic Fatigue Syndrome


Virus Unlikely to Cause Chronic Fatigue Syndrome


CFIDS Association of America
Another negative study of XMRV in CFS: Playing A Weak Hand Well



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