Society Logo
ME/CFS Australia Ltd
Please click here to donate ME/CFS Australia (SA) Inc
 
 
Facebook
 
ME/CFS AUSTRALIA (SA) INC

Registered Charity 3104

Email:
sacfs@sacfs.asn.au

Mailing address:
PO Box 322,
Modbury North,
South Australia 5092

Office:
Suite 506,
North Terrace House,
19 North Terrace,
Hackney, SA, 5069


Phone:
1300 128 339

Office Hours:
Wednesdays, 11am-3pm

ME/CFS Australia (SA) Inc supports the needs of sufferers of Myalgic Encephalomyelitis, Chronic Fatigue Syndrome and related illnesses. We do this by providing services and information to members.

Disclaimer

ME/CFS Australia (SA) Inc aims to keep members informed of various research projects, diets, medications, therapies, news items, etc. All communication, both verbal and written, is merely to disseminate information and not to make recommendations or directives.

Unless otherwise stated, the views expressed on this Web site are not necessarily the official views of the Society or its Committee and are not simply an endorsement of products or services.

Become a Member
PDF Application Form (PDF, 242KB)
Why become a member?

Costs, effectiveness associated with Fibromyalgia drugs questioned

Wednesday 30 January 2013

 

From Healio:

 

HealioCosts, effectiveness associated with increase of new central acting drugs for fibromyalgia patients questioned

Wolfe F. Eur J Pain. 2012;doi:10.1002/j.1532-2149.2012.00234.x.
January 28, 2013

New central acting drug use for treating patients with fibromyalgia has quadrupled during the last decade, but researchers were not convinced about the costly drugs’ clinical advantages, according to study results.

In a longitudinal study, researchers evaluated 3,123 patients (mean age, 54.1 years; 95.4% women) with fibromyalgia in the United States. Participants completed health questionnaires at 6-month intervals between 2000 and 2010. Severity-adjusted treatment prevalence was assessed. Health Assessment Questionnaire-Disability Index (HAQ-DI) measured the effect of the use of any new central acting drug (NCAD) on pain and fatigue, as well as functional status.

Researchers reported that opioids were used by 46.7% of patients in 2010, with 12.5% using strong opioids. Severity-adjusted strong opioid use increased from 6.3% to 11.7% during the study, while use of any opioid rose from 40% to 46.6%. At the same time, nonsteroidal anti-inflammatory drug and tricylic antidepressant use dropped from 74% to 44% and from 26.2% to 15.4%, respectively.

NCAD use increased from less than 10% to 39%, with drug discontinuation times estimated for the 25th and 50th percentiles at 1 and 2.5 years. Median daily doses for duloxetine, gabapentin and milnacipran were 60 mg, 900 mg, and 100 mg, respectively. Overall pain, fatigue and HAQ-DI scores were unchanged.

Following NCAD initiation, patients’ pain scores were reduced by 0.17 units, an improvement of 2.8%. Improvements up to 4.3% were shown by some sensitivity analyses, although fatigue or functional status did not show significant gains.

“In summary … switching to NCAD resulted in substantially increased drug costs, but not in clinically meaningful benefit,” the researchers reported. “Our results not only raise the question as to whether the new fibromyalgia therapies are truly effective, but also … whether expensive treatments with minimal benefit should be used.

“In the United States in 2011, pregabalin at 300 mg/day costs around $3,000 per year, duloxetine approximately $3,760 per year and milnacipran approximately $1,400 per year. By contrast, amitriptyline 75mg daily has an annual cost of $65.”

 

The above originally appeared here.

 


Arrow right

More Fibromyalgia News

 


 

blog comments powered by Disqus
Previous Previous Page