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PACE Chronic Fatigue Trial Was Properly Conducted, Says UK Research Watchdog

Friday 8 February 2019


Trigger Warning: This article mentions the PACE Trial positively


From UK medical journal The BMJ:



PACE chronic fatigue trial was properly conducted, says UK research watchdog

By Nigel Hawkes
BMJ 2019; 364 doi:
Published 7 February 2019
Cite this as: BMJ 2019;364:l639
Copyright © 2019 BMJ Publishing Group Ltd.

The PACE trial, which compared treatments for chronic fatigue syndrome, met all the regulatory requirements of its day and exceeded transparency requirements, the Health Research Authority has concluded.1

The judgment came in the form of a letter from Jonathan Montgomery, chair of the HRA, to Norman Lamb, chair of the House of Commons Science and Technology Committee. A member of the committee, Carol Monaghan, had raised the issue with Montgomery when he gave evidence on research integrity to its inquiry last year.

Although the HRA’s intervention will come as a comfort to the team that led the trial and to the Medical Research Council, which funded it, it is unlikely to put to bed a longstanding campaign by activists to discredit it.

PACE was a trial led by Peter White of Queen Mary University of London that compared four treatments for chronic fatigue syndrome. Its conclusions, published in the Lancet in …

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