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The Invisible Burden Of Chronic Fatigue In The Community: A Narrative Review

Wednesday 13 February 2019


From Current Rheumatology Reports:



The Invisible Burden of Chronic Fatigue in the Community: a Narrative Review

By Scott J. Fatt, Erin Cvejic, Andrew R. Lloyd, Ute Vollmer-Conna, Jessica Elise Beilharz
Chronic Pain (R Staud, Section Editor)
Curr Rheumatol Rep (2019) 21: 5.
First Online: 11 February 2019
© Springer Science+Business Media, LLC, part of Springer Nature 2019.


Purpose of Review

Unexplained fatigue is commonly reported in the general population, with varying severity. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) sits at the extreme of the fatigue continuum, yet more individuals experience unexplained prolonged fatigue (1–6-month duration) or chronic fatigue (> 6 months) that, although debilitating, does not fulfil ME/CFS criteria. This review examines the empirical literature comparing symptoms for those with prolonged fatigue, chronic fatigue and ME/CFS.

Recent Findings

Substantial overlap of self-reported psychological, physical and functional impairments exists between chronic fatigue and ME/CFS. The conversion rate from prolonged or chronic fatigue to ME/CFS is not understood. Current research has failed to uncover factors accounting for differences in fatigue trajectories, nor incorporate comprehensive, longitudinal assessments extending beyond self-reported symptoms.


Distinguishing factors between prolonged fatigue, chronic fatigue and ME/CFS remain poorly understood, highlighting a need for longitudinal studies integrating biopsychosocial approaches to inform early management and targeted rehabilitation strategies.


Myalgic encephalomyelitis,
Chronic fatigue syndrome,
Autonomic Function


Full article…




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