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Groundbreaking Research From NCNED: New Therapeutic Approach For ME/CFS

Tuesday 22 October 2019


From Australia's National Centre for Neuroimmunology and Emerging Diseases (NCNED) (via Facebook):


NCNED team


Monday 21 October 2019

NCNED researchers have discovered the pharmacological drug known as Naltrexone restores the impaired TRPM3 biomarker function in immune cells from ME/CFS patients.

NCNED is the peak research centre nationally and is internationally recognised for its world-leading research on the identification of the pathology, developing a screening test and pharmacotherapeutic intervention for ME/CFS.

NCNED researchers were the first in the world to develop the gold-standard in experimental research known as patch clamp technique in immune cells to measure TRP receptor function.

Cabanas, H, Muraki, K, Staines, D and Marshall-Gradisnik, S published these important findings in Frontiers in Immunology. The full publication will be released in the coming weeks, however, the abstract is provided below:

In this new pivotal research publication, Dr Cabanas and NCNED researchers report Naltrexone (NTX) restored TRPM3 activity in Natural Killer (NK) cells from ME/CFS patients. NCNED researchers use NK cells as a model for assessing TRPM3 and other TRP function and which reflects physiological activity in all body tissues expressing these ion channels.

This groundbreaking discovery used the advanced and gold-standard electrophysiology technique known as patch clamp in immune cells to confirm dysfunction of TRPM3 to be associated with ME/CFS pathology.

Importantly, NCNED researchers used Naltrexone, a known opioid antagonist used by ME/CFS patients, to restore significantly the impaired TRPM3 ion channel function in immune cells from ME/CFS patients.

This world first discovery suggests new potential pharmaco-therapeutic interventions in ME/CFS.

Thank you to the Stafford Fox Medical Research Foundation, Mr Douglas Stutt, the Mason Foundation, the McCusker Charitable Foundation, Mr Adrian Flack, Mr and Mrs Ian and Talei Stewart, the Alison Hunter Memorial Foundation, the Buxton Foundation, the Henty Community, the Blake Beckett Foundation, Change for ME Charity, QLD ME/CFS/FM Support Association QLD Inc, the ACT ME/CFS Society and WA ME/CFS.


Full article…



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