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Evidence Lacking For Current Fibromyalgia Therapies

Saturday 14 November 2020


From medwireNews:



Evidence lacking for current fibromyalgia therapies

By Laura Cowen
November 4, 2020
© 2020 Springer Healthcare is part of the Springer Nature Group.

medwireNews: The results of a systematic review and meta-analysis do not support the effectiveness of most therapies for reducing pain and improving quality of life (QoL) in people with fibromyalgia.

Therapies such as cognitive behavioral therapy (CBT) and antidepressants “may reduce pain and improve QOL in the short to medium term, although the effect size of the associations might not be clinically important to patients,” Vinícius Oliveira (Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil) and co-authors write in JAMA Internal Medicine.

Oliveira and team reviewed data from 224 randomized or quasi-randomized clinical trials that investigated fibromyalgia therapies among 29,962 participants.

The studies included 65 different therapies that fell into the categories of single nonpharmacologic treatments (n=36), combinations of two or more nonpharmacologic treatments (n=8), pharmacologic treatments (n=17), combinations of two or more pharmacologic treatments (n=3), or a combination of pharmacologic and nonpharmacologic therapy (n=1).

Among them, only CBT met the GRADE criteria for high-quality evidence of short-term pain reduction. Individuals who received CBT had a weighted mean reduction in visual analog scale pain score (graded on a scale of 0–10) that was a significant 0.9 points greater than that achieved by individuals in the corresponding control group.

However, the researchers note that this difference did not exceed the minimal clinically important difference (MCID) of 2 points.


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