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ME/CFS Australia Ltd
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ME/CFS South Australia Inc supports the needs of sufferers of Myalgic Encephalomyelitis, Chronic Fatigue Syndrome and related illnesses. We do this by providing services and information to members.


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The Role Of Mitochondria, Oxidative Stress And The Response To Antioxidants In ME/CFS: A Possible Approach To SARS-CoV-2 'Long-Haulers'?

Monday 7 December 2020


From Chronic Diseases and Translational Medicine:


Test tubes

Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: a possible approach to SARS-CoV-2 ‘long-haulers’?

Emily Wood, Katherine H. Hall, Warren Tate
Chronic Disease and Translational Medicine
Available online 21 November 2020
In Press, Journal Pre-proof
© 2020 Chinese Medical Association. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
Copyright © 2020 Elsevier B.V. or its licensors or contributors. ScienceDirect ® is a registered trademark of Elsevier B.V.


A significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome.

This paper reviews the current literature and understanding of the role that mitochondria, oxidative stress and antioxidants may play in the understanding of the pathophysiology and treatment of chronic fatigue.

It describes what is known about the dysfunctional pathways which can develop in mitochondria and their relationship to chronic fatigue.

It also reviews what is known about oxidative stress and how this can be related to the pathophysiology of fatigue, as well as examining the potential for specific therapy directed at mitochondria for the treatment of chronic fatigue in the form of antioxidants.

This review identifies areas which require urgent, further research in order to fully elucidate the clinical and therapeutic potential of these approaches.


Chronic fatigue syndrome, myalgic encephalitis, mitochondria, oxidative stress, antioxidants, SARS-CoV-2, COVID-19


Full article...



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