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Newcastle Lecture
Page 1: Introduction
Page 2: Ms Tania Emms
Page 3: Dr Henry Butt
Talking Point
June 2000
In this issue:
Newcastle
Lecture
Food and Chemical Sensitivities
Newcastle Team Lecture (continued)
Dr Henry Butt
Dr Henry Butt, PhD, followed Ms Tania Emms with a talk on the faecal microbial changes in CFS patients with irritable bowel. He stated that fatigue presentation in CFS patients with symptoms of irritable bowel were more severe than CFS patients without irritable bowel. Furthermore, patients with irritable bowel had poorer appetite, increased abdominal pain increased severity of loose stool / diarrhoea, nausea, and gastric reflux. Face, neck, shoulder, and lower back pain of fatigue patients with symptoms of irritable bowel were significantly more severe than fatigue patients with little or no symptoms of irritable bowel.
Dr Butt has reported the change in the faecal microbial flora of patients wih CFS preivously. This change in the gastrointestinal microbial flora may help to explain the observation of Dr Jacobs of the United Kingdom that 50% of a population of CFS patients were deficient in folic acid. Folic acid has been shown to be produced by gastrointestinal microorganisms. Dr Butt stated that folic acid is an important precursor for the synthesis of nucleic acids and proteins in all tissues, and demand for it increases during infection. However, activation of folic acid requires the presence of serine, an amino acid which is a building block of proteins. Hence, patients deficient in folic acid and serine may require a combined intake of the substances. Investigative work performed in Newcastle demonstrated a highly significant number of patients with CFS were deficient in serine. Low serine level can affect cell membrane function and integrity, and result in gut dysfunction.
Dr Butt ended with a call for volunteers diagnosed as having CFS who would like to participate in a research project to be conducted by the University of Newcastle in the city of Adelaide. The project is a clinical trial of 17 weeks aiming to determine if supplements of serine can improve the symptoms of CFS. Any patient interested in participating is invited to send their contact details to:
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Ms Tania Emms |
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10 Moore Street, |
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Page 2: Ms Tania Emms |
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